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“Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades.”
Director, National Institute of Mental Health
For the past 15 years researchers have known that tiny doses of ketamine can rapidly relieve depression symptoms when delivered via slow intravenous infusion. The first scholarly paper describing this discovery was published by Yale in 2000. Since then, dozens more studies have been conducted by Yale and other major institutions, including the National Institutes of Health, the Veterans Administration, Harvard, Johns Hopkins, Mount Sinai Medical School, Oxford University, and more. The original findings have been reconfirmed many times.
Studies to date have focused on the worst-of-the-worst cases. These are treatment-resistant patients who have suffered for years or decades, often since childhood. They have tried SSRIs, mood stabilizers, and many other medications with no success. Most have also tried standard therapies like psychological counseling or CBT, as well as alternative treatments like acupuncture, with little to no benefit. Among these extreme cases, an astonishing 70% experience rapid relief after a small IV infusion of ketamine.
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